Dancing cheek to cheek: Cryptococcus neoformans and phagocytes
نویسندگان
چکیده
Meningoencephalitis caused by Cryptococcus neoformans (Cn) has become one of the leading causes of mortality in AIDS patients. Understanding the interactions between Cn and phagocytes is fundamental in exploring the pathogenicity of cryptococcal meningoencephalitis. Cn may be extracellular or contained in the monocytes, macrophages, neutrophils, dendritic cells and even endothelial cells. The internalized Cn may proliferate inside the host cells, or cause the lysis of host cells, or leave the host cells via non-lytic exocytosis, or even hijack the host cells (Trojan horse) for the brain dissemination, which are regulated by microbe factors and also immune molecules. Coexistence of protective and deleterious roles of phagocytes in the progression of cryptococcosis warrant further investigation.
منابع مشابه
Effect of mannose-binding protein on binding of Cryptococcus neoformans to human phagocytes.
The capacity of human peripheral blood monocytes, neutrophils, and monocyte-derived macrophages to bind the yeast Cryptococcus neoformans was increased when the phagocytes were cultured on surfaces containing recombinant human mannose-binding protein. In contrast, soluble mannose-binding protein had no effect on cryptococcal binding by phagocytes.
متن کاملEffect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection.
Antifungal drugs can affect the cellular morphology of Cryptococcus neoformans in culture, which alters its interactions with phagocytes. We examined the effects of amphotericin B on C. neoformans during murine infection. The antifungal reduced capsule size and serum polysaccharide, which suggests an additional mechanism for amphotericin B's efficacy in cryptococcosis.
متن کاملCryptococcus neoformans. 3. Inhibition of phagocytosis.
Isolated nonhydrolyzed cryptococcal polysaccharide is a rather specific potent inhibitor of the phagocytosis of Cryptococcus neoformans by human leukocytes in vitro. When an encapsulated strain of C. neoformans was cultured in the nonencapsulated state, the rate of phagocytosis was three times greater than when the encapsulated form was used. Our theory that capsular material plays a role in th...
متن کاملSpontaneous differentiated squamous cell carcinoma of cheek pouch in a Syrian hamster
A 2-year-old male hamster was presented because of left facial swelling and salivation. Necropsy wasperformed and affected cheek pouch with tissue samples of regional and internal organs were submitted forhistopathological study. In histopathological examination it was found that the tumor consisted of cords andislands of tumoric epithelial cells which were diffused in the dermis. Vacoulation o...
متن کاملCryptococcus and Phagocytes: Complex Interactions that Influence Disease Outcome
Cryptococcus neoformans and C. gattii are fungal pathogens that cause life-threatening disease. These fungi commonly enter their host via inhalation into the lungs where they encounter resident phagocytes, including macrophages and dendritic cells, whose response has a pronounced impact on the outcome of disease. Cryptococcus has complex interactions with the resident and infiltrating innate im...
متن کامل